Curated Information
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PubMed Id: 11672534 
Vines CM, et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-19 11672534
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y290-p - Syk (mouse)
Orthologous residues
Syk (human): Y296‑p, Syk iso2 (human): , Syk (mouse): Y290‑p, Syk (rat): Y290‑p

Y342-p - Syk (mouse)
Orthologous residues
Syk (human): Y348‑p, Syk iso2 (human): Y325‑p, Syk (mouse): Y342‑p, Syk (rat): Y342‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FGR (mouse) SH2 Induces pull-down assay

Y346-p - Syk (mouse)
Orthologous residues
Syk (human): Y352‑p, Syk iso2 (human): Y329‑p, Syk (mouse): Y346‑p, Syk (rat): Y346‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FGR (mouse) SH2 Induces pull-down assay

Y519-p - Syk (mouse)
Orthologous residues
Syk (human): Y525‑p, Syk iso2 (human): Y502‑p, Syk (mouse): Y519‑p, Syk (rat): Y519‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BAC1 (macrophage)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGR (human) increase FGR -/-
FGR (human) decrease FGR K279R mutant

Y520-p - Syk (mouse)
Orthologous residues
Syk (human): Y526‑p, Syk iso2 (human): Y503‑p, Syk (mouse): Y520‑p, Syk (rat): Y520‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BAC1 (macrophage)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGR (human) increase FGR -/-
FGR (human) decrease FGR K279R mutant


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