Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 11672534 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vines CM, et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-19 11672534
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y290-p - Syk (mouse)
Orthologous residues
Syk (human): Y296‑p, Syk iso2 (human): , Syk (mouse): Y290‑p, Syk (rat): Y290‑p

Y342-p - Syk (mouse)
Orthologous residues
Syk (human): Y348‑p, Syk iso2 (human): Y325‑p, Syk (mouse): Y342‑p, Syk (rat): Y342‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Fgr (mouse) SH2 Induces pull-down assay

Y346-p - Syk (mouse)
Orthologous residues
Syk (human): Y352‑p, Syk iso2 (human): Y329‑p, Syk (mouse): Y346‑p, Syk (rat): Y346‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Fgr (mouse) SH2 Induces pull-down assay

Y519-p - Syk (mouse)
Orthologous residues
Syk (human): Y525‑p, Syk iso2 (human): Y502‑p, Syk (mouse): Y519‑p, Syk (rat): Y519‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BAC1 (macrophage)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Fgr (human) increase FGR -/-
Fgr (human) decrease FGR K279R mutant

Y520-p - Syk (mouse)
Orthologous residues
Syk (human): Y526‑p, Syk iso2 (human): Y503‑p, Syk (mouse): Y520‑p, Syk (rat): Y520‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BAC1 (macrophage)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Fgr (human) increase FGR -/-
Fgr (human) decrease FGR K279R mutant


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.