Curated Information
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Curated Information Page
PubMed Id: 7774014 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Franke TF, et al. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-36 7774014
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y740-p - PDGFRB (human)
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  TRMP (renal)
 Cellular systems studied:  cell lines
 Species studied:  dog
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  mediates Akt activation

Y751-p - PDGFRB (human)
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  TRMP (renal)
 Cellular systems studied:  cell lines
 Species studied:  dog
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  mediates Akt activation

Y771-p - PDGFRB (human)
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  TRMP (renal)
 Cellular systems studied:  cell lines
 Species studied:  dog

Y1009-p - PDGFRB (human)
Orthologous residues
PDGFRB (human): Y1009‑p, PDGFRB (mouse): Y1008‑p, PDGFRB (rat): Y1008‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  TRMP (renal)
 Cellular systems studied:  cell lines
 Species studied:  dog

Y1021-p - PDGFRB (human)
Orthologous residues
PDGFRB (human): Y1021‑p, PDGFRB (mouse): Y1020‑p, PDGFRB (rat): Y1020‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  TRMP (renal)
 Cellular systems studied:  cell lines
 Species studied:  dog


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