Curated Information

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Curated Information Page

PubMed Id: 7596441

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Wang Y, Prives C (1995) Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376, 88-91 7596441

S315-p - p53 (human)

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Orthologous residues

p53 (human): S315‑p, p53 (mouse): S309‑p, p53 iso2 (mouse): S312‑p, p53 (rat): S313‑p, p53 (rabbit): S313‑p, p53 (monkey): S315‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK1 (human)
KINASE	CDK2 (human)

Downstream Regulation

Effect of modification (function): molecular association, regulation, protein conformation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
DNA		Induces			EMSA

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