Curated Information

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PubMed Id: 10477747

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146, 905-16 10477747

S140-p - H2AX (human)

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Orthologous residues

H2AX (human): S140‑p, H2AX (mouse): S140‑p, H2AX (rat): S140‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: brain cancer, glioblastoma, glioma, breast cancer

Relevant cell lines - cell types - tissues: MCF-7 (breast cell), SF268 (glial)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase

Downstream Regulation

Comments: Gamma-H2AX appear as nuclear foci and correspond to double-stranded DNA breaks.

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