Curated Information
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Curated Information Page
PubMed Id: 10949293 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rea S, et al. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-9 10949293
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K10-m - H3 (human) ▲
Orthologous residues
H3 (human): K10‑m, H3 (mouse): K10‑m, H3 iso2 (mouse): K10‑m, H3 iso3 (mouse): K10‑m, H3 (rat): K10‑m, H3 iso3 (rat): K10‑m, H3 (pig): K10‑m, H3 (chicken): K10‑m, H3 (cow): K10‑m
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [SUV39H1 (mouse), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
METHYLTRANSFERASE SUV39H1 (human)
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Effect of modification (process):  chromatin organization, altered
 Comments:  inibits S10 phosphorylation

S11-p - H3 (human) ▲
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [SUV39H1 (mouse), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE AurA (human)
Downstream Regulation
 Effect of modification (function):  methylation
 Effect of modification (process):  chromatin organization, altered
 Comments:  inhibits K9 methylation


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