Curated Information
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Curated Information Page
PubMed Id: 9315650 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Lu H, Fisher RP, Bailey P, Levine AJ (1997) The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol 17, 5923-34 9315650
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S371-p - p53 (human)
Orthologous residues
p53 (human): S371‑p, p53 (mouse): T365‑p, p53 iso2 (mouse): , p53 (rat): T369‑p, p53 (rabbit): A369‑p, p53 (monkey): S371‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces molecular association, regulation transcription, altered EMSA, in vitro

S376-p - p53 (human)
Orthologous residues
p53 (human): S376‑p, p53 (mouse): S370‑p, p53 iso2 (mouse): , p53 (rat): S374‑p, p53 (rabbit): S374‑p, p53 (monkey): S376‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces molecular association, regulation transcription, altered EMSA, in vitro

T377-p - p53 (human)
Orthologous residues
p53 (human): T377‑p, p53 (mouse): T371‑p, p53 iso2 (mouse): , p53 (rat): T375‑p, p53 (rabbit): T375‑p, p53 (monkey): T377‑p

S378-p - p53 (human)
Orthologous residues
p53 (human): S378‑p, p53 (mouse): S372‑p, p53 iso2 (mouse): , p53 (rat): S376‑p, p53 (rabbit): S376‑p, p53 (monkey): S378‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces molecular association, regulation transcription, altered EMSA, in vitro

S392-p - p53 (human)
Orthologous residues
p53 (human): S392‑p, p53 (mouse): S386‑p, p53 iso2 (mouse): , p53 (rat): S390‑p, p53 (rabbit): S390‑p, p53 (monkey): S392‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces molecular association, regulation transcription, altered EMSA, in vitro


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