Curated Information
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PubMed Id: 19454314 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Makkinje A, et al. (2009) AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal 21, 1423-35 19454314
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S139-p - P130Cas (human)
Orthologous residues
P130Cas (human): S139‑p, P130Cas (mouse): S143‑p, P130Cas (rat): S237‑p, P130Cas iso2 (rat): S143‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF-7 (breast cell) [BCAR3 (human), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BCAR3 (human) increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered

S437-p - P130Cas (human)
Orthologous residues
P130Cas (human): S437‑p, P130Cas (mouse): S441‑p, P130Cas (rat): S535‑p, P130Cas iso2 (rat): S441‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF-7 (breast cell) [BCAR3 (human), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BCAR3 (human) increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered

S639-p - P130Cas (human)
Orthologous residues
P130Cas (human): S639‑p, P130Cas (mouse): S643‑p, P130Cas (rat): S737‑p, P130Cas iso2 (rat): S643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MCF-7 (breast cell) [BCAR3 (human), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BCAR3 (human) increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered

S143-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): S139‑p, P130Cas (mouse): S143‑p, P130Cas (rat): S237‑p, P130Cas iso2 (rat): S143‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human

S441-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): S437‑p, P130Cas (mouse): S441‑p, P130Cas (rat): S535‑p, P130Cas iso2 (rat): S441‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human

S643-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): S639‑p, P130Cas (mouse): S643‑p, P130Cas (rat): S737‑p, P130Cas iso2 (rat): S643‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human


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