Curated Information

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Curated Information Page

PubMed Id: 7925280

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Gouilleux F, Wakao H, Mundt M, Groner B (1994) Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 13, 4361-9 7925280

Y694-p - STAT5A (sheep)

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Orthologous residues

STAT5A (human): Y694‑p, STAT5A (mouse): Y694‑p, STAT5A iso2 (mouse): ‑, STAT5A (rat): Y694‑p, STAT5A (fruit fly): Y711‑p, STAT5A (sheep): Y694‑p

Characterization

Methods used to characterize site in vivo: electrophoretic mobility shift, immunoprecipitation, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	JAK2 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
PRL		increase
staurosporine	PRL	inhibit treatment-induced increase
genistein	PRL	inhibit treatment-induced increase

Downstream Regulation

Effect of modification (function): activation

Effect of modification (process): transcription, altered

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