Curated Information

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Home

Curated Information Page

PubMed Id: 19438505

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Masson K, et al. (2009) A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Br J Haematol 146, 193-202 19438505

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y768-p - FLT3 (human)

▲

Orthologous residues

FLT3 (human): Y768‑p, FLT3 (mouse): Y769‑p, FLT3 iso3 (mouse): Y769‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: BaF3 ('B lymphocyte, precursor'), COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FL				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): cell cycle regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
Grb2 (human)		Induces	molecular association, regulation		co-immunoprecipitation

Comments: regulates cell proliferation

Y955-p - FLT3 (human)

▲

Orthologous residues

FLT3 (human): Y955‑p, FLT3 (mouse): I958‑p, FLT3 iso3 (mouse): Y958‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: BaF3 ('B lymphocyte, precursor'), COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FL				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): cell cycle regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
Grb2 (human)		Induces	molecular association, regulation		co-immunoprecipitation

Comments: regulates cell proliferation

Y969-p - FLT3 (human)

▲

Orthologous residues

FLT3 (human): Y969‑p, FLT3 (mouse): Q971‑p, FLT3 iso3 (mouse): Y972‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: BaF3 ('B lymphocyte, precursor'), COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FL				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): cell cycle regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
Grb2 (human)		Induces	molecular association, regulation		co-immunoprecipitation

Comments: regulates cell proliferation

Home \| Curator Login	With enhanced literature mining using Linguamatics I2E		Produced by 3rd Millennium \| Design by Digizyme
			©2003-2013 Cell Signaling Technology, Inc.