Curated Information
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Curated Information Page
PubMed Id: 16782030 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gomez TS, et al. (2006) HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 24, 741-52 16782030
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y378-p - HS1 (human)
Orthologous residues
HS1 (human): Y378‑p, HS1 (mouse): Y388‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-blood
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Syk (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization, transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
VAV1 (human) Induces cytoskeletal reorganization co-immunoprecipitation

Y397-p - HS1 (human)
Orthologous residues
HS1 (human): Y397‑p, HS1 (mouse): Y405‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-blood
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Syk (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
anti-CD3 increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization, transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
VAV1 (human) Induces cytoskeletal reorganization co-immunoprecipitation


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