|
Orthologous residues
|
|
K17 (human): T9‑p, K17 (mouse): T9‑p, K17 (rat): T9‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
BHK (fibroblast)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
mouse
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Effect of modification (process):
cell cycle regulation
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
14-3-3 sigma (human)
|
|
Not reported
|
|
|
chemical cross-linking
|
|
|
Comments:
Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389.
|
