Curated Information
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Curated Information Page
PubMed Id: 16439361 
Gray P, et al. (2006) MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281, 10489-95 16439361
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y86-p - TIRAP (human)
Orthologous residues
TIRAP (human): Y86‑p, TIRAP (mouse): Y106‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Btk (human)
Downstream Regulation
 Effect of modification (function):  activity, induced

Y106-p - TIRAP (human)
Orthologous residues
TIRAP (human): Y106‑p, TIRAP (mouse): Y126‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Btk (human)
Downstream Regulation
 Effect of modification (function):  activity, induced

Y187-p - TIRAP (human)
Orthologous residues
TIRAP (human): Y187‑p, TIRAP (mouse): Y207‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Btk (human)
Downstream Regulation
 Effect of modification (function):  activity, induced


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