Curated Information
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Curated Information Page
PubMed Id: 16581786 
Liu Y, et al. (2006) The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. Mol Cell Biol 26, 3114-23 16581786
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S641-p - ELF4 (human)
Orthologous residues
ELF4 (human): S641‑p, ELF4 (mouse): S633‑p, ELF4 (rat): S631‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  protein degradation

T643-p - ELF4 (human)
Orthologous residues
ELF4 (human): T643‑p, ELF4 (mouse): T635‑p, ELF4 (rat): T633‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK2 (human)
Downstream Regulation
 Effect of modification (function):  protein degradation

S648-p - ELF4 (human)
Orthologous residues
ELF4 (human): S648‑p, ELF4 (mouse): S640‑p, ELF4 (rat): S638‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK2 (human)
Downstream Regulation
 Effect of modification (function):  protein degradation
 Comments:  phosphorylation of this site is required for ELF4 ubiquitination


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