Curated Information

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Curated Information Page

PubMed Id: 12205041

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Werz O, et al. (2002) Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J 16, 1441-3 12205041

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S272-p - 5-LO (human)

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Orthologous residues

5‑LO (human): S272‑p, 5‑LO (mouse): S272‑p, 5‑LO (rat): S271‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

S664-p - 5-LO (human)

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Orthologous residues

5‑LO (human): S664‑p, 5‑LO (mouse): S664‑p, 5‑LO (rat): S663‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ERK2 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
arachidonic acid				increase
oleic acid				increase
linoleic acid				increase

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