Curated Information

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Curated Information Page

PubMed Id: 15263083

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Pitula JS, et al. (2004) Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. Proc Natl Acad Sci U S A 101, 10907-12 15263083

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S711-p - IREB1 (human)

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Orthologous residues

IREB1 (human): S711‑p, IREB1 (mouse): S711‑p, IREB1 (rat): S711‑p, IREB1 (rabbit): S711‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human, yeast

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKCA (human)	pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
phorbol ester				increase

Downstream Regulation

Comments: regulates citrate-to-isocitrate activity of cytosolic aconitase in yeast extracts

S711-p - IREB1 (rabbit)

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Orthologous residues

IREB1 (human): S711‑p, IREB1 (mouse): S711‑p, IREB1 (rat): S711‑p, IREB1 (rabbit): S711‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCA (cow)

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