Curated Information
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Curated Information Page
PubMed Id: 16551632 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vandermoere F, et al. (2006) The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival. J Biol Chem 281, 14307-13 16551632
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S352-p - VCP (human) ▲
Orthologous residues
VCP (human): S352‑p, VCP (mouse): S352‑p, VCP (rat): S352‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody, siRNA inhibition of enzyme
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited

S746-p - VCP (human) ▲
Orthologous residues
VCP (human): S746‑p, VCP (mouse): S746‑p, VCP (rat): S746‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody, siRNA inhibition of enzyme
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited

S748-p - VCP (human) ▲
Orthologous residues
VCP (human): S748‑p, VCP (mouse): S748‑p, VCP (rat): S748‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody, siRNA inhibition of enzyme
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited


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