Curated Information
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Curated Information Page
PubMed Id: 16508002 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rushworth LK, Hindley AD, O'Neill E, Kolch W (2006) Regulation and role of Raf-1/B-Raf heterodimerization. Mol Cell Biol 26, 2262-72 16508002
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T753-p - BRAF (human)
Orthologous residues
BRAF (human): T753‑p, BRAF (mouse): T790‑p, BRAF iso3 (mouse): , BRAF (rat): T790‑p, BRAF (chicken): T793‑p, BRAF (quail): T793‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) pharmacological inhibitor of upstream enzyme
KINASE ERK1 (human) pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAF1 (human) Disrupts


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