Curated Information
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Curated Information Page
PubMed Id: 16549426 
Li X, et al. (2006) Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. J Biol Chem 281, 13837-43 16549426
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T72-p - Akt1 (human)
Orthologous residues
Akt1 (human): T72‑p, Akt1 (mouse): T72‑p, Akt1 (rat): T72‑p, Akt1 (fruit fly): T175‑p, Akt1 (cow): T72‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
 Comments:  requires phosphorylation of sites S473 and T308
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  apoptosis, inhibited
 Comments:  doxorubicin-induced apoptosis

S246-p - Akt1 (human)
Orthologous residues
Akt1 (human): S246‑p, Akt1 (mouse): S246‑p, Akt1 (rat): S246‑p, Akt1 (fruit fly): T362‑p, Akt1 (cow): S246‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
 Comments:  requires phosphorylation of sites S473 and T308
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  apoptosis, inhibited
 Comments:  doxorubicin-induced apoptosis


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