Curated Information
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Curated Information Page
PubMed Id: 9190208 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Connell-Crowley L, Harper JW, Goodrich DW (1997) Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 8, 287-301 9190208
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T252-p - Rb (human)
Orthologous residues
Rb (human): T252‑p, Rb (mouse): T246‑p, Rb (rat): T245‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK4 (human)
KINASE CDK2 (human)

T356-p - Rb (human)
Orthologous residues
Rb (human): T356‑p, Rb (mouse): T350‑p, Rb (rat): T349‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK4 (human)
KINASE CDK2 (human)

T373-p - Rb (human)
Orthologous residues
Rb (human): T373‑p, Rb (mouse): T367‑p, Rb (rat): T366‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK2 (human)
KINASE CDK4 (human)

S788-p - Rb (human)
Orthologous residues
Rb (human): S788‑p, Rb (mouse): S781‑p, Rb (rat): S780‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK4 (human)

S795-p - Rb (human)
Orthologous residues
Rb (human): S795‑p, Rb (mouse): S788‑p, Rb (rat): S787‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  MOLT-4 (T lymphocyte), Saos-2 (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK4 (human)
Downstream Regulation
 Effect of modification (process):  cell cycle regulation


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