Curated Information

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Curated Information Page

PubMed Id: 9190208

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Connell-Crowley L, Harper JW, Goodrich DW (1997) Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 8, 287-301 9190208

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T252-p - Rb (human)

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Orthologous residues

Rb (human): T252‑p, Rb (mouse): T246‑p, Rb (rat): T245‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK4 (human)
KINASE	CDK2 (human)

T356-p - Rb (human)

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Orthologous residues

Rb (human): T356‑p, Rb (mouse): T350‑p, Rb (rat): T349‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK2 (human)
KINASE	CDK4 (human)

T373-p - Rb (human)

▲

Orthologous residues

Rb (human): T373‑p, Rb (mouse): T367‑p, Rb (rat): T366‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK4 (human)
KINASE	CDK2 (human)

S788-p - Rb (human)

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Orthologous residues

Rb (human): S788‑p, Rb (mouse): S781‑p, Rb (rat): S780‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK4 (human)

S795-p - Rb (human)

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Orthologous residues

Rb (human): S795‑p, Rb (mouse): S788‑p, Rb (rat): S787‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping

Relevant cell lines - cell types - tissues: MOLT-4 (T lymphocyte), Saos-2 (bone cell)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK4 (human)

Downstream Regulation

Effect of modification (process): cell cycle regulation

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