Curated Information
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Curated Information Page
PubMed Id: 16531993 
Lomberk G, Bensi D, Fernandez-Zapico ME, Urrutia R (2006) Evidence for the existence of an HP1-mediated subcode within the histone code. Nat Cell Biol 8, 407-15 16531993
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S93-p - CBX3 (human)
Orthologous residues
CBX3 (human): S93‑p, CBX3 iso3 (human): , CBX3 (mouse): S93‑p, CBX3 (rat): S93‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) antisense inhibition of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
staurosporine decrease
staurosporine, forskolin increase
KT5720 decrease
siRNA decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Ku70 (human) Not reported co-immunoprecipitation, microscopy-colocalization
 Comments:  may regulate gene expression and silencing


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