Curated Information

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Curated Information Page

PubMed Id: 9003781

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kitagawa M, et al. (1996) The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15, 7060-9 9003781

S780-p - Rb (human)

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Orthologous residues

Rb (human): S780‑p, Rb (mouse): S773‑p, Rb (rat): S772‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, phospho-antibody, western blotting

Disease tissue studied: brain cancer, glioblastoma, glioblastoma multiforme, glioma, breast cancer

Relevant cell lines - cell types - tissues: FM3A (breast cell), T98G (glial)

Cellular systems studied: cell lines

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK4 (human)

Comments: Cyclin D/CDK4

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
serum				increase

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