Curated Information
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Curated Information Page
PubMed Id: 11551923 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Otipoby KL, Draves KE, Clark EA (2001) CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1. J Biol Chem 276, 44315-22 11551923
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y783-p - CD22 iso4 (mouse) ▲
Orthologous residues
CD22 (human): Y762‑p, CD22 iso2 (human): Y585‑p, CD22 (mouse): Y777‑p, CD22 iso4 (mouse): Y783‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y817-p - CD22 iso4 (mouse) ▲
Orthologous residues
CD22 (human): Y796‑p, CD22 iso2 (human): Y619‑p, CD22 (mouse): Y811‑p, CD22 iso4 (mouse): Y817‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

Y828-p - CD22 iso4 (mouse) ▲
Orthologous residues
CD22 (human): Y807‑p, CD22 iso2 (human): Y630‑p, CD22 (mouse): Y822‑p, CD22 iso4 (mouse): Y828‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) Induces in vitro

Y843-p - CD22 iso4 (mouse) ▲
Orthologous residues
CD22 (human): Y822‑p, CD22 iso2 (human): Y645‑p, CD22 (mouse): Y837‑p, CD22 iso4 (mouse): Y843‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) Induces co-immunoprecipitation

Y863-p - CD22 iso4 (mouse) ▲
Orthologous residues
CD22 (human): Y842‑p, CD22 iso2 (human): Y665‑p, CD22 (mouse): Y857‑p, CD22 iso4 (mouse): Y863‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) Induces co-immunoprecipitation


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