Curated Information
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Curated Information Page
PubMed Id: 16498080 
Chen Z, et al. (2006) Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species. Am J Respir Cell Mol Biol 35, 127-32 16498080
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T156-p - AP2M1 (human)
Orthologous residues
AP2M1 (human): T156‑p, AP2M1 iso2 (human): T154‑p, AP2M1 (mouse): T156‑p, AP2M1 iso3 (mouse): T154‑p, AP2M1 (rat): T156‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  A549 (pulmonary), OK (renal)
 Cellular systems studied:  cell lines
 Species studied:  opossum
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dopamine increase
bisindolylmaleimide dopamine inhibit treatment-induced increase
staurosporine dopamine inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ATP1A1 (human) Not reported intracellular localization co-immunoprecipitation
 Comments:  important for endocytosis

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