Curated Information
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PubMed Id: 10866658 
Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20, 5010-8 10866658
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S370-p - PTEN (human)
Orthologous residues
PTEN (human): S370‑p, PTEN iso2 (human): S543‑p, PTEN (mouse): S370‑p, PTEN (rat): S370‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human

S380-p - PTEN (human)
Orthologous residues
PTEN (human): S380‑p, PTEN iso2 (human): S553‑p, PTEN (mouse): S380‑p, PTEN (rat): S380‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered

T382-p - PTEN (human)
Orthologous residues
PTEN (human): T382‑p, PTEN iso2 (human): T555‑p, PTEN (mouse): T382‑p, PTEN (rat): T382‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered

T383-p - PTEN (human)
Orthologous residues
PTEN (human): T383‑p, PTEN iso2 (human): T556‑p, PTEN (mouse): T383‑p, PTEN (rat): T383‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered


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