Curated Information
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Curated Information Page
PubMed Id: 10866658 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20, 5010-8 10866658
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S370-p - PTEN (human)
Orthologous residues
PTEN (human): S370‑p, PTEN (mouse): S370‑p, PTEN (rat): S370‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human

S380-p - PTEN (human)
Orthologous residues
PTEN (human): S380‑p, PTEN (mouse): S380‑p, PTEN (rat): S380‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered

T382-p - PTEN (human)
Orthologous residues
PTEN (human): T382‑p, PTEN (mouse): T382‑p, PTEN (rat): T382‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered

T383-p - PTEN (human)
Orthologous residues
PTEN (human): T383‑p, PTEN (mouse): T383‑p, PTEN (rat): T383‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, protein stabilization
 Effect of modification (process):  transcription, altered


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