Curated Information
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Curated Information Page
PubMed Id: 19473992 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yang X, et al. (2009) Plk1-mediated phosphorylation of Topors regulates p53 stability. J Biol Chem 284, 18588-92 19473992
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S718-p - TOPORS (human)
Orthologous residues
TOPORS (human): S718‑p, TOPORS (mouse): S718‑p, TOPORS (rat): S719‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) siRNA inhibition of enzyme
Downstream Regulation
 Effect of modification (function):  sumoylation, ubiquitination
 Comments:  inhibits sumoylation but induces ubiquitination of p53


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