Curated Information

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Curated Information Page

PubMed Id: 10753910

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Flynn P, Mellor H, Casamassima A, Parker PJ (2000) Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. J Biol Chem 275, 11064-70 10753910

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T774-p - PKN1 (human)

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Orthologous residues

PKN1 (human): T774‑p, PKN1 (mouse): T778‑p, PKN1 (rat): T778‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial) [PDK1 (human)], 293 (epithelial) [RhoA (human)], 293 (epithelial) [RhoB (human)]

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PDK1 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PDK1 (human)	genetic transfer of constitutively active upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
LY294002				decrease

Downstream Regulation

Effect of modification (function): enzymatic activity, induced

T816-p - PKN2 (human)

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