Curated Information
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Curated Information Page
PubMed Id: 19265112 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Saleh A, et al. (2009) Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway smooth muscle cells. J Immunol 182, 3357-65 19265112
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y705-p - STAT3 (human) ▲
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'muscle, smooth'
 Cellular systems studied:  cell lines
 Comments:  airway smooth muscle; Disease, asthma
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase IL-17A
JAK2 inhibitor inhibit treatment-induced increase
JAK3 inhibitor I inhibit treatment-induced increase
U0126 no effect upon treatment-induced increase
SB203580 no change compared to control
SB600125 inhibit treatment-induced increase
IL-4 increase
SB203580 IL-4 inhibit treatment-induced increase
U0126 IL-4 inhibit treatment-induced increase
SB600125 IL-4 inhibit treatment-induced increase
JAK2 inhibitor IL-4 inhibit treatment-induced increase
JAK3 inhibitor I IL-4 inhibit treatment-induced increase

S727-p - STAT3 (human) ▲
Orthologous residues
STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 iso3 (human): ‑, STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): ‑, STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  'muscle, smooth'
 Cellular systems studied:  primary cells
 Species studied:  human
Downstream Regulation
 Effect of modification (process):  transcription, altered

Y694-p - STAT5A (human) ▲
Orthologous residues
STAT5A (human): Y694‑p, STAT5A (mouse): Y694‑p, STAT5A iso2 (mouse): ‑, STAT5A (rat): Y694‑p, STAT5A (fruit fly): Y711‑p, STAT5A (sheep): Y694‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'muscle, smooth'
 Cellular systems studied:  cell lines
 Comments:  airway smooth muscle; Disease, asthma
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
no change compared to control IL-17A

Y641-p - STAT6 (human) ▲
Orthologous residues
STAT6 (human): Y641‑p, STAT6 (mouse): Y641‑p, STAT6 (rat): Y641‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'muscle, smooth'
 Cellular systems studied:  cell lines
 Comments:  airway smooth muscle; Disease, asthma
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
no change compared to control IL-17A


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