Curated Information
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Curated Information Page
PubMed Id: 19117545 
Ozcan L, et al. (2009) Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9, 35-51 19117545
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S724-p - IRE1 (mouse)
Orthologous residues
IRE1 (human): S724‑p, IRE1 (mouse): S724‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hypothalamus', 293 (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

T980-p - PERK (mouse)
Orthologous residues
PERK (human): T982‑p, PERK (mouse): T980‑p, PERK (rat): T974‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hypothalamus', 293 (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase
tauroursodeoxycholic acid decrease
butyrate decrease wild-type (lean) and ob/ob (obese mice)

Y705-p - STAT3 (mouse)
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hypothalamus', 293 (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
tunicamycin decrease
leptin tunicamycin inhibit treatment-induced decrease
DTT decrease
leptin DTT inhibit treatment-induced decrease
XBP1 (mouse) no change compared to control
leptin increase
tunicamycin leptin no effect upon treatment-induced increase
ATF6A (mouse) no change compared to control
leptin increase
tunicamycin leptin no effect upon treatment-induced increase
leptin increase wild-type (lean) mice
leptin decrease ob/ob (obese) mice


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