Curated Information
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Curated Information Page
PubMed Id: 10893237 
Yue C, et al. (2000) Molecular mechanism of the inhibition of phospholipase C beta 3 by protein kinase C. J Biol Chem 275, 30220-5 10893237
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S1105-p - PLCB3 (human)
Orthologous residues
PLCB3 (human): S1105‑p, PLCB3 (mouse): S1105‑p, PLCB3 (rat): S1105‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical), PHM1-49 (myometrial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase


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