Curated Information
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Curated Information Page
PubMed Id: 19254572 
Qi L, et al. (2009) Adipocyte CREB promotes insulin resistance in obesity. Cell Metab 9, 277-86 19254572
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  hepatocyte-liver
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase

T183-p - AMPKA1 (mouse)
Orthologous residues
AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  hepatocyte-liver
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase wild-type
no change compared to control ob/ob mice
no change compared to control ACREB (dominant negative)
forskolin, adiponectin increase

S133-p - CREB (mouse)
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  diabetes mellitus, type 2 diabetes
 Relevant cell lines - cell types - tissues:  hepatocyte-liver
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
high-fat diet increase
increase obese (db) mouse

S171-p - TORC2 (mouse)
Orthologous residues
TORC2 (human): S171‑p, TORC2 (mouse): S171‑p, TORC2 (rat): S171‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  hepatocyte-liver
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
no change compared to control wild-type, ob/ob mice, and ACREB mice
forskolin ADIPOR1 (mouse) no change compared to control CRTC2 S171A mutant
insulin forskolin ADIPOR1 (mouse) no change compared to control
forskolin ADIPOR1 (mouse) increase wild-type CRTC2
insulin forskolin ADIPOR1 (mouse) inhibit treatment-induced increase
forskolin, adiponectin increase


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