Curated Information
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PubMed Id: 19303854 
Ezhkova E, et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136, 1122-35 19303854
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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K27-m3 - H3 (mouse)
Orthologous residues
H3 (human): K27‑m3, H3 (mouse): K27‑m3, H3 iso2 (mouse): K27‑m3, H3 iso3 (mouse): K27‑m3, H3 (rat): K27‑m3, H3 iso3 (rat): K27‑m3, H3 (pig): K27‑m3, H3 (chicken): K27‑m3, H3 (cow): K27‑m3
 Methods used to characterize site in vivo western blotting
 Relevant cell lines - cell types - tissues:  epidermal [EZH2 (mouse), homozygous knockout]
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE EZH2 (mouse) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EZH2 (mouse) increase EZH2 -/- inhibits
Downstream Regulation
 Effect of modification (process):  transcription, altered

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