Curated Information

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PubMed Id: 19303854

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Ezhkova E, et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136, 1122-35 19303854

K28-m3 - H3 (mouse)

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Orthologous residues

H3 (human): K28‑m3, H3 (mouse): K28‑m3, H3 iso2 (mouse): K28‑m3, H3 iso3 (mouse): K28‑m3, H3 (rat): K28‑m3, H3 iso3 (rat): K28‑m3, H3 (pig): K28‑m3, H3 (chicken): K28‑m3, H3 (cow): K28‑m3

Characterization

Methods used to characterize site in vivo: western blotting

Relevant cell lines - cell types - tissues: epidermal [EZH2 (mouse), homozygous knockout]

Cellular systems studied: primary cells

Species studied: mouse

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
METHYLTRANSFERASE	EZH2 (mouse)	genetic knockout/knockin of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		EZH2 (mouse)		increase	EZH2 -/- inhibits

Downstream Regulation

Effect of modification (process): transcription, altered

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