Curated Information
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PubMed Id: 19303846 
Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31 19303846
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T222-p - C/EBP-alpha (mouse)
Orthologous residues
C/EBP‑alpha (human): T226‑p, C/EBP‑alpha (mouse): T222‑p, C/EBP‑alpha (rat): T222‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

T226-p - C/EBP-alpha (mouse)
Orthologous residues
C/EBP‑alpha (human): T230‑p, C/EBP‑alpha (mouse): T226‑p, C/EBP‑alpha (rat): T226‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

S33-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S37-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

T41-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S9-p - GSK3B (mouse)
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

Y216-p - GSK3B (mouse)
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S231-p - neurogenin 2 (mouse)
Orthologous residues
neurogenin 2 (human): S239‑p, neurogenin 2 (mouse): S231‑p, neurogenin 2 (rat): S231‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

S234-p - neurogenin 2 (mouse)
Orthologous residues
neurogenin 2 (human): S242‑p, neurogenin 2 (mouse): S234‑p, neurogenin 2 (rat): S234‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control


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