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PubMed Id: 19303846

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31 19303846

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T222-p - C/EBP-alpha (mouse)

▲

Orthologous residues

C/EBP‑alpha (human): T226‑p, C/EBP‑alpha (mouse): T222‑p, C/EBP‑alpha (rat): T222‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		DISC1 (mouse)		no change compared to control
siRNA		DISC1 (mouse)		no change compared to control

T226-p - C/EBP-alpha (mouse)

▲

Orthologous residues

C/EBP‑alpha (human): T230‑p, C/EBP‑alpha (mouse): T226‑p, C/EBP‑alpha (rat): T226‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		DISC1 (mouse)		no change compared to control
siRNA		DISC1 (mouse)		no change compared to control

S33-p - CTNNB1 (mouse)

▲

Orthologous residues

CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
siRNA		DISC1 (mouse)		increase
		DISC1 (human)		decrease

S37-p - CTNNB1 (mouse)

▲

Orthologous residues

CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
siRNA		DISC1 (mouse)		increase
		DISC1 (human)		decrease

T41-p - CTNNB1 (mouse)

▲

Orthologous residues

CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
siRNA		DISC1 (mouse)		increase
		DISC1 (human)		decrease

S9-p - GSK3B (mouse)

▲

Orthologous residues

GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		DISC1 (mouse)		no change compared to control
siRNA		DISC1 (mouse)		no change compared to control

Y216-p - GSK3B (mouse)

▲

Orthologous residues

GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): ‑

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
siRNA		DISC1 (mouse)		increase
		DISC1 (human)		decrease

S231-p - neurogenin 2 (mouse)

▲

Orthologous residues

neurogenin 2 (human): S239‑p, neurogenin 2 (mouse): S231‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		DISC1 (mouse)		no change compared to control
siRNA		DISC1 (mouse)		no change compared to control

S234-p - neurogenin 2 (mouse)

▲

Orthologous residues

neurogenin 2 (human): S242‑p, neurogenin 2 (mouse): S234‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, cerebral cortical'-brain, 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: mouse

Comments: adult hippocampal progenitor cells (AHPs)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		DISC1 (mouse)		no change compared to control
siRNA		DISC1 (mouse)		no change compared to control

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