Curated Information
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Curated Information Page
PubMed Id: 19359662 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Pan S, World CJ, Kovacs CJ, Berk BC (2009) Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler Thromb Vasc Biol 29, 895-901 19359662
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y428-p - G6PD (human)
Orthologous residues
G6PD (human): Y428‑p, G6PD iso3 (human): Y458‑p, G6PD (mouse): Y428‑p, G6PD (rat): Y428‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  EC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) pharmacological activator of upstream enzyme, modification site within consensus motif, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
Downstream Regulation
 Effect of modification (process):  cell motility, altered
 Comments:  modulates Akt activity

Y507-p - G6PD (human)
Orthologous residues
G6PD (human): Y507‑p, G6PD iso3 (human): Y537‑p, G6PD (mouse): Y507‑p, G6PD (rat): Y507‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  EC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) pharmacological activator of upstream enzyme, modification site within consensus motif, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
Downstream Regulation
 Effect of modification (process):  cell motility, altered
 Comments:  modulates Akt activity


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