Curated Information
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Curated Information Page
PubMed Id: 19339247 
Shi B, Tran T, Sobkoviak R, Pope RM (2009) Activation-induced Degradation of FLIPL Is Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages. J Biol Chem 284, 14513-23 19339247
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S273-p - CFLAR (human)
Orthologous residues
CFLAR (human): S273‑p, CFLAR iso2 (human): , CFLAR (mouse): S278‑p
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  RAW 264.7 (macrophage)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) modification site within consensus motif, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  protein degradation

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