Curated Information
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Curated Information Page
PubMed Id: 10490106 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chen H, et al. (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98, 675-86 10490106
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K616-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K616‑ac, SRC‑3 (mouse): K609‑ac, SRC‑3 (rat): K316‑ac
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)

K619-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K619‑ac, SRC‑3 (mouse): K612‑ac, SRC‑3 (rat): K319‑ac
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CV1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ER-alpha (human) Disrupts EMSA

K620-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K620‑ac, SRC‑3 (mouse): K613‑ac, SRC‑3 (rat): K320‑ac
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CV1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ER-alpha (human) Disrupts EMSA


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