Curated Information
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Curated Information Page
PubMed Id: 10490106 
Chen H, et al. (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98, 675-86 10490106
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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K616-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K616‑ac, SRC‑3 iso2 (human): K616‑ac, SRC‑3 (mouse): K609‑ac, SRC‑3 (rat): K316‑ac
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)

K619-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K619‑ac, SRC‑3 iso2 (human): K619‑ac, SRC‑3 (mouse): K612‑ac, SRC‑3 (rat): K319‑ac
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CV1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ER-alpha (human) Disrupts EMSA

K620-ac - SRC-3 (human)
Orthologous residues
SRC‑3 (human): K620‑ac, SRC‑3 iso2 (human): K620‑ac, SRC‑3 (mouse): K613‑ac, SRC‑3 (rat): K320‑ac
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CV1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ER-alpha (human) Disrupts EMSA


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