Curated Information
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Curated Information Page
PubMed Id: 11433299 
Chan HM, et al. (2001) Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol 3, 667-74 11433299
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K873-ac - Rb (human)
Orthologous residues
Rb (human): K873‑ac, Rb (mouse): K866‑ac, Rb (rat): K865‑ac
Characterization
 Methods used to characterize site in vivo immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting
 Disease tissue studied:  bone cancer, brain cancer, glioblastoma multiforme, glioma
 Relevant cell lines - cell types - tissues:  293 (epithelial), Saos-2 (bone cell), T98G (glial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Effect of modification (process):  cell cycle regulation
 Comments:  reduced level of CDK-dependent phosphorylation of Rb KK873/874QQ mutant

K874-ac - Rb (human)
Orthologous residues
Rb (human): K874‑ac, Rb (mouse): K867‑ac, Rb (rat): K866‑ac
Characterization
 Methods used to characterize site in vivo immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting
 Disease tissue studied:  bone cancer, brain cancer, glioblastoma multiforme, glioma
 Relevant cell lines - cell types - tissues:  293 (epithelial), Saos-2 (bone cell), T98G (glial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Effect of modification (process):  cell cycle regulation
 Comments:  reduced level of CDK-dependent phosphorylation of Rb KK873/874QQ mutant


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