Curated Information
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Curated Information Page
PubMed Id: 18775435 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Chen S, O'Reilly LP, Smithgall TE, Engen JR (2008) Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. J Mol Biol 383, 414-23 18775435
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y70-p - Abl (human)
Orthologous residues
Abl (human): Y70‑p, Abl iso2 (human): Y89‑p, Abl (mouse): Y70‑p, Abl iso2 (mouse): Y89‑p, Abl (rat): Y70‑p, Abl iso2 (rat): Y89‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Hck (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Abi-1 (human) Disrupts co-immunoprecipitation, in vitro
 Comments:  Y70 phosphorylation blocks Abl SH3 binding to Abi-1 regulatory protein.

Y226-p - Abl (human)
Orthologous residues
Abl (human): Y226‑p, Abl iso2 (human): Y245‑p, Abl (mouse): Y226‑p, Abl iso2 (mouse): Y245‑p, Abl (rat): Y226‑p, Abl iso2 (rat): Y245‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Hck (human)

Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Hck (human)


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