Curated Information
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Curated Information Page
PubMed Id: 16243840 
Evans GJ, et al. (2006) Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. J Biol Chem 281, 1564-72 16243840
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S10-p - DNAJC5 (rat)
Orthologous residues
DNAJC5 (human): S10‑p, DNAJC5 iso2 (human): S10‑p, DNAJC5 (mouse): S10‑p, DNAJC5 (rat): S10‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), chromaffin-adrenal gland
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  cow, human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme

S473-p - Akt1 (cow)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  chromaffin-adrenal gland
 Cellular systems studied:  primary cultured cells
 Species studied:  cow
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase

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