|
Orthologous residues
|
|
IMP‑1 (human): Y396‑p, IMP‑1 (mouse): Y396‑p, IMP‑1 (rat): Y396‑p, IMP‑1 (chicken): Y396‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial) [IMP-1 (human)], 293 (epithelial) [Src (human)], NG108-15 (neuron) [IMP-1 (human)], NG108-15 (neuron) [Src (human)]
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Src (human)
|
transfection of inactive enzyme, transfection of constitutively active enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
inhibition, molecular association, regulation
|
|
Comments:
IMP-1 Y396 phosphorylation interferes with its binding to beta-actin mRNA, thereby promoting beta-actin translation.
|
