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Orthologous residues
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GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
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Characterization
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Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
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|
Relevant cell lines - cell types - tissues:
HeLa S3 (cervical)
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|
Cellular systems studied:
cell lines
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Species studied:
human
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Enzymes shown to modify site in vitro:
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|
|
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Upstream Regulation
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Potential in vivo enzymes for site:
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Type
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Enzyme
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Evidence
|
Notes
|
|
KINASE
|
p90RSK (human)
|
pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme, modification site within consensus motif, phosphopeptide analysis, transfection of wild-type enzyme
|
|
|
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Downstream Regulation
|
|
Effect of modification (function):
enzymatic activity, inhibited
|
