Curated Information

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Curated Information Page

PubMed Id: 9694798

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Partanen J, Schwartz L, Rossant J (1998) Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 12, 2332-44 9694798

Y766-p - FGFR1 (mouse)

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Orthologous residues

FGFR1 (human): Y766‑p, FGFR1 iso21 (human): Y797‑p, FGFR1 (mouse): Y766‑p, FGFR1 (rat): Y673‑p, FGFR1 iso2 (rat): Y766‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: embryo [FGFR1 (mouse), transgenic]

Cellular systems studied: tissue

Species studied: mouse

Downstream Regulation

Effect of modification (process): cell growth, altered, transcription, altered

Comments: Y766F mutation causes embryonic transformations in vertebral column.

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