Curated Information

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Curated Information Page

PubMed Id: 18701889

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Soroceanu L, Akhavan A, Cobbs CS (2008) Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection. Nature 455, 391-5 18701889

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S473-p - Akt1 (human)

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Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: leukemia, erythroid leukemia

Relevant cell lines - cell types - tissues: fibroblast, HEL (erythroid)

Cellular systems studied: cell lines, primary cultured cells

Species studied: human, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect	Notes
PDGF		increase
anti-PDGFR	PDGF	inhibit treatment-induced increase	IMC-3C3 blocking antibody
imatinib	PDGF	inhibit treatment-induced increase
virus infection		increase	HCMV (human cytomegalovirus)
anti-PDGFR	virus infection	inhibit treatment-induced increase	IMC-3G3 blocking antibody
imatinib	virus infection	inhibit treatment-induced increase

Y754-p - PDGFRa (human)

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