Curated Information
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Curated Information Page
PubMed Id: 18252867 
Peiser M, et al. (2008) Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. J Leukoc Biol 83, 1118-27 18252867
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S376-p - IRAK1 (human)
Orthologous residues
IRAK1 (human): S376‑p, IRAK1 iso4 (human): S376‑p, IRAK1 (mouse): S376‑p, IRAK1 (rat): S376‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  monocyte
 Cellular systems studied:  primary cultured cells
 Species studied:  human
 Comments:  monocyte derived CD1c+ MoLCs
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS no change compared to control
Pam3CSK4 increase
MALP-2 no change compared to control

T387-p - IRAK1 (human)
Orthologous residues
IRAK1 (human): T387‑p, IRAK1 iso4 (human): T387‑p, IRAK1 (mouse): T387‑p, IRAK1 (rat): T387‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  monocyte
 Cellular systems studied:  primary cultured cells
 Species studied:  human
 Comments:  monocyte derived CD1c+ MoLCs
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase slight increase
Pam3CSK4 increase
MALP-2 no change compared to control


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