Curated Information

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Curated Information Page

PubMed Id: 11375271

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Camper-Kirby D, et al. (2001) Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 88, 1020-7 11375271

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S473-p - Akt1 (human)

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Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: myocyte-heart

Cellular systems studied: primary cultured cells, tissue

Species studied: human, mouse

Downstream Regulation

Effect of modification (function): intracellular localization

Comments: nuclear localization induced by genistein and estradiol in female mice

S473-p - Akt1 (mouse)

▲

Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: myocyte-heart

Cellular systems studied: primary cultured cells, tissue

Species studied: human, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
IGF-1				increase
genistein				increase
estrogen				increase

Downstream Regulation

Effect of modification (function): intracellular localization

Comments: nuclear localization induced by genistein and estradiol in female mice

S253-p - FOXO1A (mouse)

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Orthologous residues

FOXO1A (human): S256‑p, FOXO1A (mouse): S253‑p, FOXO1A (rat): S250‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: myocyte-heart

Cellular systems studied: primary cultured cells, tissue

Species studied: human, mouse

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Akt1 (mouse)	pharmacological activator of upstream enzyme, phospho-antibody

Downstream Regulation

Effect of modification (function): intracellular localization

Comments: cytoplasmic localization induced by genistein and estradiol in female mice

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