Curated Information
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PubMed Id: 11375271 
Camper-Kirby D, et al. (2001) Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 88, 1020-7 11375271
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  nuclear localization induced by genistein and estradiol in female mice

S473-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
genistein increase
estrogen increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  nuclear localization induced by genistein and estradiol in female mice

S253-p - FOXO1A (mouse)
Orthologous residues
FOXO1A (human): S256‑p, FOXO1A (mouse): S253‑p, FOXO1A (rat): S250‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (mouse) phospho-antibody, pharmacological activator of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  cytoplasmic localization induced by genistein and estradiol in female mice


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