Curated Information
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Curated Information Page
PubMed Id: 16378098 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Goto H, et al. (2006) Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol 8, 180-7 16378098
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T59-p - INCENP (mouse) ▲
Orthologous residues
INCENP (human): T59‑p, INCENP (mouse): T59‑p, INCENP (rat): T59‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)

T388-p - INCENP (mouse) ▲
Orthologous residues
INCENP (human): T412‑p, INCENP (mouse): T388‑p, INCENP (rat): T401‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLK1 (human) Induces co-immunoprecipitation
 Comments:  phosphorylation plays important role in recruitment of Plk1 to kinetochores and progression of cell cycle

S861-p - INCENP (mouse) ▲
Orthologous residues
INCENP (human): S893‑p, INCENP (mouse): S861‑p, INCENP (rat): S877‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE AurB (human)

S862-p - INCENP (mouse) ▲
Orthologous residues
INCENP (human): S894‑p, INCENP (mouse): S862‑p, INCENP (rat): S878‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE AurB (human)


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