Curated Information
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Curated Information Page
PubMed Id: 16357147 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Woerner BM, et al. (2005) Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res 65, 11392-9 16357147
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S339-p - CXCR4 (human)
Orthologous residues
CXCR4 (human): S339‑p, CXCR4 (mouse): S346‑p, CXCR4 (rat): S336‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  glial, LN428 (glial), U87MG (glial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SDF-1alpha increase
EGF increase
phorbol ester increase


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