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Orthologous residues
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IP3R1 (human): S2690‑p, IP3R1 iso3 (human): S2642‑p, IP3R1 (mouse): S2681‑p, IP3R1 iso2 (mouse): S2666‑p, IP3R1 (rat): S2682‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
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Relevant cell lines - cell types - tissues:
COS (fibroblast), DT40 (B lymphocyte)
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Cellular systems studied:
cell lines
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Species studied:
monkey
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Enzymes shown to modify site in vitro:
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Upstream Regulation
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Potential in vivo enzymes for site:
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Type
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Enzyme
|
Evidence
|
Notes
|
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KINASE
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Akt1 (human)
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transfection of constitutively active enzyme
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Treatments, proteins and their effect on site modification:
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Treatments
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Referenced Treatments
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Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
insulin
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|
|
|
increase
|
|
|
LY294002
|
insulin
|
|
|
inhibit treatment-induced increase
|
|
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LY294002
|
|
|
|
decrease
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
inhibition
|
|
Comments:
staurosporin-induced caspase-3 activation was enhanced in cells expressing S2682A mutant IP3R1.
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