Curated Information
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Curated Information Page
PubMed Id: 16338927 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hers I, et al. (2006) Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. J Biol Chem 281, 4762-70 16338927
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S330-p - DLC1 (rat)
Orthologous residues
DLC1 (human): S766‑p, DLC1 (mouse): S331‑p, DLC1 iso2 (mouse): S365‑p, DLC1 (rat): S330‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Cellular systems studied:  cell lines, primary cells
 Species studied:  hamster, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE p90RSK (human)
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
U0126 insulin inhibit treatment-induced increase
wortmannin insulin no effect upon treatment-induced increase
U0126, wortmannin insulin inhibit treatment-induced increase
rapamycin insulin no effect upon treatment-induced increase
insulin increase
wortmannin insulin inhibit treatment-induced increase
U0126 insulin no effect upon treatment-induced increase


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