Curated Information

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PubMed Id: 16314523

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Stegert MR, et al. (2005) Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol Cell Biol 25, 11019-29 16314523

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S282-p - NDR2 (human)

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Orthologous residues

NDR2 (human): S282‑p, NDR2 (mouse): S282‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293F (epithelial), COS (fibroblast)

Cellular systems studied: cell lines

Species studied: human, monkey

Comments: kinase-dead mutant K119A was used in this study

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	NDR2 (human)	pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
okadaic acid				increase

Downstream Regulation

Effect of modification (function): enzymatic activity, induced

T442-p - NDR2 (human)

▲

Orthologous residues

NDR2 (human): T442‑p, NDR2 (mouse): T442‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293F (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	MST3 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	MST3 (human)	transfection of inactive enzyme, pharmacological activator of upstream enzyme, transfection of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
okadaic acid				increase

Downstream Regulation

Effect of modification (function): enzymatic activity, induced, phosphorylation

Comments: phosphorylation of this site enhances autophosphorylation of S307

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