Curated Information

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Curated Information Page

PubMed Id: 14603323

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Busino L, et al. (2003) Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426, 87-91 14603323

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S82-p - Cdc25A (human)

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Orthologous residues

Cdc25A (human): S82‑p, Cdc25A iso2 (human): S82‑p, Cdc25A (mouse): S80‑p, Cdc25A (rat): S82‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: HeLa (cervical) [BTRC (human)], HeLa (cervical) [Cdc25A (human)], HeLa (cervical) [FBW1B (human)]

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase

Downstream Regulation

Effect of modification (function): protein degradation

Effect of modification (process): cell cycle regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
FBW1B (human)		Induces
BTRC (human)		Induces

S88-p - Cdc25A (human)

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