Curated Information
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Curated Information Page
PubMed Id: 14603323 
Busino L, et al. (2003) Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426, 87-91 14603323
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S82-p - CDC25A (human)
Orthologous residues
CDC25A (human): S82‑p, CDC25A iso2 (human): S82‑p, CDC25A (mouse): S81‑p, CDC25A (rat): S82‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [BTRC (human)], HeLa (cervical) [CDC25A (human)], HeLa (cervical) [FBW1B (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
Downstream Regulation
 Effect of modification (function):  protein degradation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBW1B (human) Induces
BTRC (human) Induces

S88-p - CDC25A (human)
Orthologous residues
CDC25A (human): S88‑p, CDC25A iso2 (human): S88‑p, CDC25A (mouse): S87‑p, CDC25A (rat): S88‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [BTRC (human)], HeLa (cervical) [CDC25A (human)], HeLa (cervical) [FBW1B (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
Downstream Regulation
 Effect of modification (function):  protein degradation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBW1B (human) Induces
BTRC (human) Induces


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